- Quarterback Carson Palmer (Cincinnati Bengals) completed 23-of-35 pass attempts for 259 yards and 1 touchdown in the Bengals' 28-17 loss to Houston.
- Linebacker Keith Rivers (Cincinnati Bengals) had 6 tackles in the Bengals' loss.
- Linebacker Brian Cushing (Houston Texans) had 9 tackles, an interception and two forced fumbles in the Texans' win.
- Linebacker Clay Matthews (Green Bay Packers) had 5 tackles, including 2 sacks, in the Packers' 26-0 win over Detroit.
- Tailback Reggie Bush (New Orleans Saints) had 6 carries for 17 yards and 1 touchdown along with 1 reception for 7 yards in the Saints' 48-27 win over New York.
- Wideout Steve Smith (New York Giants) had 4 receptions for 44 yards in the Giants' loss.
- Safety Troy Polamalu (Pittsburgh Steelers) had 1 interception and 4 tackles in his return from injury as the Steelers won 27-14 over Cleveland.
- Quarterback Matt Cassel (Kansas City Chiefs) went 17-for-32 and threw for 186 yards in the Chiefs' 14-6 win over Washington.
- Tight end Fred Davis (Washington Redskins) had 1 reception for 12 yards in the Redskins' loss.
- Quarterback Matt Leinart (Arizona Cardinals) completed 2-of-2 pass attempts for 16 yards in the Cardinals' 27-3 win over Seattle.
- Lofa Tatupu (Seattle Seahawks) had 8 tackles in the Seahawks' loss.
- Tailback Justin Fargas (Oakland Raiders) had 23 carries for 87 yards in the Raiders' 13-9 win over Philadelphia.
- Linebacker Junior Seau (New England Patriots) had 2 tackles in his return to football as the Patriots beat the Titans 59-0.
- Quarterback Mark Sanchez (New York Jets) completed 10-of-29 passes for 119 yards and five interceptions in the Jets' 16-13 loss to Buffalo.
In his first game back from retirement, linebacker Junior Seau had two tackles in the Patriots' 59-0 win over Tennessee on Sunday.
